Motif ID: NFY{A,B,C}.p2

Z-value: 4.588


Transcription factors associated with NFY{A,B,C}.p2:

Gene SymbolEntrez IDGene Name
NFYA 4800 nuclear transcription factor Y, alpha
NFYB 4801 nuclear transcription factor Y, beta
NFYC 4802 nuclear transcription factor Y, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFYCchr1_+_409300800.943.9e-08Click!
NFYAchr6_+_411486650.852.5e-05Click!
NFYBchr12_-_1030559240.204.5e-01Click!


Activity profile for motif NFY{A,B,C}.p2.

activity profile for motif NFY{A,B,C}.p2


Sorted Z-values histogram for motif NFY{A,B,C}.p2

Sorted Z-values for motif NFY{A,B,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFY{A,B,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_23175383 7.278 NM_005794
NM_182908
DHRS2

dehydrogenase/reductase (SDR family) member 2

chr17_+_78009895 5.489 NARF
nuclear prelamin A recognition factor
chr17_+_78009819 5.187 NM_001083608
NM_012336
NM_031968
NARF


nuclear prelamin A recognition factor


chr1_+_225194560 5.066 NM_020247
ADCK3
aarF domain containing kinase 3
chr1_+_225194582 4.959 ADCK3
aarF domain containing kinase 3
chr1_+_225194616 4.920 ADCK3
aarF domain containing kinase 3
chr17_-_35827568 4.794 NM_001067
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr1_+_225194622 4.624 ADCK3
aarF domain containing kinase 3
chr17_+_23670247 4.515 NM_014573
TMEM97
transmembrane protein 97
chr17_-_53950191 4.499 NM_004687
MTMR4
myotubularin related protein 4
chr4_-_174492029 4.441 NM_001130688
NM_002129
HMGB2

high-mobility group box 2

chr19_-_14108400 4.357 NM_018154
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr14_-_54438913 4.196 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr17_+_54587641 4.052 NM_018304
PRR11
proline rich 11
chr1_+_110683586 3.829 RBM15
RNA binding motif protein 15
chr1_+_70649451 3.813 NM_001190463
NM_001902
NM_153742
CTH


cystathionase (cystathionine gamma-lyase)


chr1_-_147665783 3.806 HIST2H2BF
histone cluster 2, H2bf
chr1_+_110683580 3.806 RBM15
RNA binding motif protein 15
chrX_+_47999740 3.755 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr2_+_74914742 3.669 HK2
hexokinase 2
chr11_-_67645433 3.665 NM_001277
NM_212469
CHKA

choline kinase alpha

chrX_-_132947141 3.515 GPC3
glypican 3
chr7_-_150305933 3.504 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chrX_+_52797004 3.480 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chrX_-_132947290 3.460 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr1_-_180627512 3.436 GLUL
glutamate-ammonia ligase
chr1_-_159257486 3.436 F11R
F11 receptor
chr1_-_27689129 3.418 WASF2
WAS protein family, member 2
chr17_+_78009336 3.393 NM_001038618
NARF
nuclear prelamin A recognition factor
chr19_-_14108267 3.380 ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chrX_-_52700674 3.354 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr2_+_26862416 3.345 CENPA
centromere protein A
chr6_-_26164478 3.326 NM_005319
HIST1H1C
histone cluster 1, H1c
chr11_-_73371945 3.261 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr15_-_39412032 3.259 NM_007280
OIP5
Opa interacting protein 5
chr17_+_70256397 3.239 SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr17_-_45196516 3.231 NM_030802
FAM117A
family with sequence similarity 117, member A
chr17_+_16225130 3.227


chr17_-_77573974 3.207 NM_144998
STRA13
stimulated by retinoic acid 13 homolog (mouse)
chr15_-_20929608 3.138 HERC2P2
hect domain and RLD 2 pseudogene 2
chr17_-_45196465 3.062 FAM117A
family with sequence similarity 117, member A
chr12_+_6473552 3.015 NM_014865
NCAPD2
non-SMC condensin I complex, subunit D2
chr6_-_26305456 3.011 HIST1H3D
histone cluster 1, H3d
chr15_+_39412447 2.984 NUSAP1
nucleolar and spindle associated protein 1
chr2_-_96238296 2.959 NM_020151
STARD7
StAR-related lipid transfer (START) domain containing 7
chr9_+_130883199 2.954 NM_001135917
NM_020438
DOLPP1

dolichyl pyrophosphate phosphatase 1

chr6_+_80771108 2.893 TTK
TTK protein kinase
chr1_-_148080888 2.890 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr16_+_162845 2.881 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr12_+_6473519 2.880 NCAPD2
non-SMC condensin I complex, subunit D2
chr16_-_57221235 2.875 CNOT1
CCR4-NOT transcription complex, subunit 1
chr17_+_70256389 2.857 SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr16_+_166678 2.834 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr11_-_67645246 2.829 CHKA
choline kinase alpha
chr1_-_159257567 2.813 F11R
F11 receptor
chr14_+_23654161 2.808 DCAF11
DDB1 and CUL4 associated factor 11
chr17_+_70256341 2.804 NM_004252
SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr6_+_26381122 2.802 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr2_+_238540361 2.791 UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr2_-_61618898 2.779 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr14_+_23654307 2.777 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr2_-_96238234 2.751 STARD7
StAR-related lipid transfer (START) domain containing 7
chr1_-_223682394 2.750 NM_002296
LBR
lamin B receptor
chr2_-_128501334 2.711 NM_001145928
NM_024545
SAP130

Sin3A-associated protein, 130kDa

chr1_-_223682324 2.668 LBR
lamin B receptor
chr12_-_120715937 2.659 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr11_-_19219000 2.643 NM_024680
E2F8
E2F transcription factor 8
chr20_+_47096189 2.607 NM_001316
CSE1L
CSE1 chromosome segregation 1-like (yeast)
chr3_-_187771025 2.552 NM_001134415
TBCCD1
TBCC domain containing 1
chr1_+_12002098 2.522 NM_021933
MIIP
migration and invasion inhibitory protein
chr13_-_29937966 2.508 HMGB1
HMGB1P6
high-mobility group box 1
high-mobility group box 1 pseudogene 6
chr6_+_80771040 2.504 NM_001166691
NM_003318
TTK

TTK protein kinase

chr3_-_9414122 2.503 LOC440944
hypothetical LOC440944
chr1_+_12002138 2.495 MIIP
migration and invasion inhibitory protein
chr5_-_149772563 2.483 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_-_209915443 2.474 NM_002497
NEK2
NIMA (never in mitosis gene a)-related kinase 2
chr19_-_45948211 2.447 C19orf54
chromosome 19 open reading frame 54
chr17_+_70256370 2.430 SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr5_-_131160541 2.407 FNIP1
folliculin interacting protein 1
chr5_+_44844724 2.389 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr5_+_70918856 2.389 NM_022132
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr16_-_57221240 2.380 NM_016284
NM_206999
CNOT1

CCR4-NOT transcription complex, subunit 1

chr1_+_51968046 2.377 NM_148904
NM_148905
NM_148907
OSBPL9


oxysterol binding protein-like 9


chr6_-_166716353 2.374 BRP44L
brain protein 44-like
chr22_-_27467776 2.351 NM_001005735
NM_007194
NM_145862
CHEK2


CHK2 checkpoint homolog (S. pombe)


chr19_-_1993022 2.346 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr9_+_4782833 2.342 NM_005772
RCL1
RNA terminal phosphate cyclase-like 1
chr2_-_96237665 2.338 STARD7
StAR-related lipid transfer (START) domain containing 7
chr6_+_24883133 2.332 NM_015895
GMNN
geminin, DNA replication inhibitor
chr17_+_54587882 2.330 PRR11
proline rich 11
chr1_+_51968096 2.319 OSBPL9
oxysterol binding protein-like 9
chr14_+_23653848 2.314 DCAF11
DDB1 and CUL4 associated factor 11
chr5_+_70918888 2.312 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr9_+_134895882 2.312 NM_001122823
NM_012087
GTF3C5

general transcription factor IIIC, polypeptide 5, 63kDa

chr15_+_39412183 2.311 NM_001129897
NM_016359
NM_018454
NUSAP1


nucleolar and spindle associated protein 1


chr2_-_234427884 2.303 HJURP
Holliday junction recognition protein
chr14_+_23653745 2.298 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr1_+_148089251 2.287 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr19_+_50086350 2.283 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_47552238 2.271 NM_001048166
NM_003035
STIL

SCL/TAL1 interrupting locus

chr2_+_26862368 2.271 NM_001809
NM_001042426
CENPA

centromere protein A

chr13_-_29938029 2.266 NM_002128
HMGB1
high-mobility group box 1
chr2_+_86521999 2.255 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr2_-_234427921 2.254 NM_018410
HJURP
Holliday junction recognition protein
chr9_+_134896194 2.251 GTF3C5
general transcription factor IIIC, polypeptide 5, 63kDa
chr5_+_162820094 2.249 NM_001142556
NM_001142557
NM_012484
NM_012485
HMMR



hyaluronan-mediated motility receptor (RHAMM)



chr1_+_110683467 2.249 NM_022768
RBM15
RNA binding motif protein 15
chr7_-_156495985 2.247 NM_005515
MNX1
motor neuron and pancreas homeobox 1
chr1_-_43945597 2.236 LOC100132774
hypothetical LOC100132774
chr5_+_70918893 2.235 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr5_-_149772469 2.233 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr14_+_23653819 2.231 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr10_-_69267774 2.222 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr11_+_63710206 2.219 STIP1
stress-induced-phosphoprotein 1
chr9_-_6635564 2.184 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr6_+_32515596 2.167 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr19_+_54962075 2.147 AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr6_-_31938530 2.143 NEU1
sialidase 1 (lysosomal sialidase)
chr1_-_195382189 2.135 NM_018136
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr1_+_51968191 2.119 OSBPL9
oxysterol binding protein-like 9
chr5_+_70918935 2.117 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr1_-_28113540 2.116 RPA2
replication protein A2, 32kDa
chr20_-_45418818 2.106 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr6_-_31938572 2.102 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr2_-_111152075 2.102 NM_004336
BUB1
budding uninhibited by benzimidazoles 1 homolog (yeast)
chr1_-_24067347 2.090 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr2_+_10180304 2.086 NM_001034
RRM2
ribonucleotide reductase M2
chr1_+_210525490 2.066 NM_006243
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr16_+_31792615 2.064 ZNF267
zinc finger protein 267
chr3_+_195336625 2.054 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr19_-_45888259 2.053 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr17_+_43373887 2.050 NM_018129
PNPO
pyridoxamine 5'-phosphate oxidase
chr8_+_6553278 2.048 NM_018361
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr14_+_38714111 2.041 NM_002687
PNN
pinin, desmosome associated protein
chr3_-_187770790 2.029 TBCCD1
TBCC domain containing 1
chr2_+_86521939 2.026 KDM3A
lysine (K)-specific demethylase 3A
chr16_+_45281078 1.993 ORC6
PPA2
origin recognition complex, subunit 6
pyrophosphatase (inorganic) 2
chr1_+_148125090 1.992 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr11_+_63710242 1.989 STIP1
stress-induced-phosphoprotein 1
chr3_+_123036719 1.985 NM_018456
EAF2
ELL associated factor 2
chr7_+_137795387 1.985 NM_003852
NM_015905
TRIM24

tripartite motif containing 24

chr2_+_47483795 1.985 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr14_-_57834558 1.960 FLJ31306
hypothetical LOC379025
chr10_+_62208256 1.936 CDK1
cyclin-dependent kinase 1
chr16_+_56327168 1.933 KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr3_-_52542748 1.924 NM_001134231
NT5DC2
5'-nucleotidase domain containing 2
chr20_+_60744231 1.912 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr10_+_62208094 1.904 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr2_+_47483750 1.898 NM_000251
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr16_-_55042614 1.897 NM_007006
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr20_+_60744268 1.894 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr1_+_24158887 1.893 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr17_-_73694669 1.883 NM_003258
TK1
thymidine kinase 1, soluble
chr1_+_24158898 1.881 PNRC2
proline-rich nuclear receptor coactivator 2
chr17_-_77261028 1.871 NM_001040025
ARL16
ADP-ribosylation factor-like 16
chr7_+_98908449 1.869 NM_001013258
NM_213603
ZNF789

zinc finger protein 789

chr19_-_17377383 1.863 NM_004335
BST2
bone marrow stromal cell antigen 2
chr11_+_63710162 1.848 NM_006819
STIP1
stress-induced-phosphoprotein 1
chr6_+_43005214 1.820 CNPY3
canopy 3 homolog (zebrafish)
chr8_-_145612636 1.804 NM_017767
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr15_+_26876480 1.800


chr9_+_4782876 1.798 RCL1
RNA terminal phosphate cyclase-like 1
chr6_+_37245860 1.796 NM_002648
PIM1
pim-1 oncogene
chr10_-_101180191 1.793 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr6_+_26307691 1.792 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr1_+_51855343 1.786 OSBPL9
oxysterol binding protein-like 9
chr3_+_9414290 1.779 NM_001080517
SETD5
SET domain containing 5
chr11_+_34417109 1.773 CAT
catalase
chr6_-_31890765 1.769 NM_005527
HSPA1L
heat shock 70kDa protein 1-like
chr7_-_150306169 1.748 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr2_+_10180145 1.747 NM_001165931
RRM2
ribonucleotide reductase M2
chr22_-_40672493 1.735 CENPM
centromere protein M
chr19_+_50086362 1.732 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_148126089 1.731 NM_175065
HIST2H2AB
HIST2H2BE
histone cluster 2, H2ab
histone cluster 2, H2be
chr2_+_162908869 1.711 GCA
grancalcin, EF-hand calcium binding protein
chr2_+_47483694 1.710 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr15_+_57184568 1.708 NM_004701
CCNB2
cyclin B2
chr2_-_61618849 1.706 XPO1
exportin 1 (CRM1 homolog, yeast)
chr1_-_148050534 1.706 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr2_-_61618871 1.706 XPO1
exportin 1 (CRM1 homolog, yeast)
chr12_-_26877189 1.705 NM_002223
ITPR2
inositol 1,4,5-triphosphate receptor, type 2
chr1_+_62674913 1.704 NM_003368
USP1
ubiquitin specific peptidase 1
chr1_-_109742020 1.690 NM_002959
SORT1
sortilin 1
chr1_-_19101603 1.687 NM_003748
NM_170726
ALDH4A1

aldehyde dehydrogenase 4 family, member A1

chr2_+_27128024 1.683 AGBL5
ATP/GTP binding protein-like 5
chr7_+_137795719 1.680 TRIM24
tripartite motif containing 24
chr8_-_145713959 1.676 NM_004260
RECQL4
RecQ protein-like 4
chrX_+_48127911 1.674 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr19_+_50086357 1.672 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr16_+_31792578 1.669 NM_003414
ZNF267
zinc finger protein 267
chr3_+_195336631 1.666 HES1
hairy and enhancer of split 1, (Drosophila)
chr4_-_84254873 1.661 PLAC8
placenta-specific 8
chr6_+_43005126 1.651 CNPY3
canopy 3 homolog (zebrafish)
chr1_-_167721723 1.649 NM_006996
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr6_-_42821815 1.640 NM_003192
TBCC
tubulin folding cofactor C
chr1_-_35431318 1.638 SFPQ
splicing factor proline/glutamine-rich
chr16_+_2419418 1.636 CCNF
cyclin F
chrX_-_48661226 1.635 NM_006875
PIM2
pim-2 oncogene
chr11_-_46824416 1.626 NM_001008938
NM_014756
CKAP5

cytoskeleton associated protein 5

chr1_+_148726537 1.624 NM_025150
TARS2
threonyl-tRNA synthetase 2, mitochondrial (putative)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.54 3.25e-27 GO:0022403 cell cycle phase
2.98 1.59e-25 GO:0000279 M phase
2.29 4.91e-23 GO:0022402 cell cycle process
2.12 7.46e-23 GO:0007049 cell cycle
2.53 8.40e-23 GO:0000278 mitotic cell cycle
3.17 1.06e-20 GO:0000087 M phase of mitotic cell cycle
2.35 4.96e-19 GO:0051276 chromosome organization
3.09 1.56e-18 GO:0000280 nuclear division
3.09 1.56e-18 GO:0007067 mitosis
2.97 2.55e-17 GO:0048285 organelle fission
4.13 1.22e-14 GO:0065004 protein-DNA complex assembly
3.60 1.94e-14 GO:0071103 DNA conformation change
2.64 2.28e-14 GO:0051301 cell division
3.87 2.36e-14 GO:0006323 DNA packaging
3.97 3.61e-14 GO:0071824 protein-DNA complex subunit organization
1.65 2.17e-13 GO:0006996 organelle organization
2.49 1.18e-12 GO:0010564 regulation of cell cycle process
4.10 1.31e-12 GO:0031497 chromatin assembly
4.10 3.34e-12 GO:0006334 nucleosome assembly
1.51 3.82e-12 GO:0090304 nucleic acid metabolic process
3.84 9.61e-12 GO:0034728 nucleosome organization
2.23 2.01e-11 GO:0006325 chromatin organization
3.35 4.39e-11 GO:0006333 chromatin assembly or disassembly
2.70 3.94e-10 GO:0071156 regulation of cell cycle arrest
2.71 8.81e-10 GO:0000075 cell cycle checkpoint
3.59 1.32e-09 GO:0007059 chromosome segregation
1.29 1.35e-09 GO:0044260 cellular macromolecule metabolic process
2.34 4.52e-09 GO:0051325 interphase
3.83 6.14e-09 GO:0000236 mitotic prometaphase
1.92 6.75e-09 GO:0051726 regulation of cell cycle
2.32 1.50e-08 GO:0051329 interphase of mitotic cell cycle
1.43 1.97e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.45 3.88e-08 GO:0006355 regulation of transcription, DNA-dependent
1.36 6.11e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.90 1.41e-07 GO:0006259 DNA metabolic process
1.32 1.47e-07 GO:0034641 cellular nitrogen compound metabolic process
1.42 1.88e-07 GO:0051252 regulation of RNA metabolic process
1.39 2.50e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.31 6.14e-07 GO:0006807 nitrogen compound metabolic process
1.35 1.12e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.18 1.57e-06 GO:0044237 cellular metabolic process
1.37 1.99e-06 GO:0010468 regulation of gene expression
1.35 2.83e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30 3.59e-06 GO:0060255 regulation of macromolecule metabolic process
1.34 5.64e-06 GO:0071842 cellular component organization at cellular level
1.33 7.27e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.28 8.47e-06 GO:0031323 regulation of cellular metabolic process
1.33 1.58e-05 GO:0009889 regulation of biosynthetic process
1.33 1.61e-05 GO:0031326 regulation of cellular biosynthetic process
1.27 1.93e-05 GO:0080090 regulation of primary metabolic process
2.65 3.42e-05 GO:0006310 DNA recombination
1.20 7.51e-05 GO:0043170 macromolecule metabolic process
1.16 1.18e-04 GO:0044238 primary metabolic process
2.88 1.70e-04 GO:0007126 meiosis
2.88 1.70e-04 GO:0051327 M phase of meiotic cell cycle
1.30 1.84e-04 GO:0009058 biosynthetic process
2.85 2.26e-04 GO:0051321 meiotic cell cycle
1.23 2.63e-04 GO:0019222 regulation of metabolic process
1.38 2.82e-04 GO:0016070 RNA metabolic process
1.57 3.02e-04 GO:0033554 cellular response to stress
2.43 4.16e-04 GO:0000082 G1/S transition of mitotic cell cycle
1.88 4.20e-04 GO:0034622 cellular macromolecular complex assembly
1.74 4.67e-04 GO:0006974 response to DNA damage stimulus
1.91 6.56e-04 GO:0006281 DNA repair
2.27 7.27e-04 GO:0006260 DNA replication
1.37 9.93e-04 GO:0034645 cellular macromolecule biosynthetic process
1.36 1.10e-03 GO:0009059 macromolecule biosynthetic process
1.86 1.55e-03 GO:0016568 chromatin modification
1.58 1.64e-03 GO:0065003 macromolecular complex assembly
1.23 1.95e-03 GO:0016043 cellular component organization
1.13 1.99e-03 GO:0008152 metabolic process
1.28 2.15e-03 GO:0044249 cellular biosynthetic process
1.22 2.36e-03 GO:0071840 cellular component organization or biogenesis
3.62 2.43e-03 GO:0000819 sister chromatid segregation
1.68 2.99e-03 GO:0034621 cellular macromolecular complex subunit organization
4.37 3.60e-03 GO:0006271 DNA strand elongation involved in DNA replication
6.05 4.14e-03 GO:0051983 regulation of chromosome segregation
5.46 4.21e-03 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
1.61 5.58e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.61 5.62e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.99 5.72e-03 GO:0007017 microtubule-based process
1.49 7.55e-03 GO:0043933 macromolecular complex subunit organization
4.05 1.04e-02 GO:0022616 DNA strand elongation
3.82 1.05e-02 GO:0006695 cholesterol biosynthetic process
2.41 1.06e-02 GO:0051320 S phase
1.40 1.41e-02 GO:0044085 cellular component biogenesis
2.68 1.57e-02 GO:0000216 M/G1 transition of mitotic cell cycle
6.79 2.02e-02 GO:0002566 somatic diversification of immune receptors via somatic mutation
6.79 2.02e-02 GO:0016446 somatic hypermutation of immunoglobulin genes
3.45 2.22e-02 GO:0000070 mitotic sister chromatid segregation
1.57 2.38e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
3.09 3.12e-02 GO:0051053 negative regulation of DNA metabolic process
1.43 3.20e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.40 3.83e-02 GO:0022607 cellular component assembly
2.33 4.37e-02 GO:0000086 G2/M transition of mitotic cell cycle
1.29 4.73e-02 GO:0010467 gene expression

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.50 1.78e-42 GO:0005634 nucleus
1.30 1.14e-39 GO:0043227 membrane-bounded organelle
1.30 1.18e-39 GO:0043231 intracellular membrane-bounded organelle
1.26 6.70e-37 GO:0043226 organelle
1.26 8.85e-37 GO:0043229 intracellular organelle
1.19 5.87e-33 GO:0044424 intracellular part
1.17 6.55e-31 GO:0005622 intracellular
2.74 9.39e-30 GO:0005694 chromosome
2.80 7.50e-26 GO:0044427 chromosomal part
1.60 2.69e-19 GO:0070013 intracellular organelle lumen
1.61 9.37e-19 GO:0044428 nuclear part
1.32 1.26e-18 GO:0044446 intracellular organelle part
1.57 1.49e-18 GO:0031974 membrane-enclosed lumen
1.57 6.90e-18 GO:0043233 organelle lumen
1.31 7.16e-18 GO:0044422 organelle part
1.65 9.21e-18 GO:0031981 nuclear lumen
2.90 1.49e-14 GO:0000785 chromatin
1.46 1.49e-13 GO:0043228 non-membrane-bounded organelle
1.46 1.49e-13 GO:0043232 intracellular non-membrane-bounded organelle
1.67 6.69e-13 GO:0005654 nucleoplasm
3.81 9.49e-12 GO:0032993 protein-DNA complex
3.32 9.87e-12 GO:0000793 condensed chromosome
4.69 1.43e-11 GO:0000786 nucleosome
1.33 5.80e-10 GO:0032991 macromolecular complex
2.85 6.70e-10 GO:0044454 nuclear chromosome part
2.62 1.03e-09 GO:0000228 nuclear chromosome
3.06 5.59e-09 GO:0000775 chromosome, centromeric region
4.02 3.75e-07 GO:0000794 condensed nuclear chromosome
2.47 1.67e-06 GO:0005819 spindle
1.74 1.88e-06 GO:0015630 microtubule cytoskeleton
3.22 3.16e-05 GO:0000779 condensed chromosome, centromeric region
2.99 5.46e-05 GO:0000776 kinetochore
6.24 1.02e-04 GO:0042613 MHC class II protein complex
3.15 1.78e-04 GO:0000777 condensed chromosome kinetochore
3.22 2.15e-04 GO:0000922 spindle pole
1.25 3.86e-04 GO:0043234 protein complex
1.10 1.14e-03 GO:0005737 cytoplasm
2.86 3.23e-03 GO:0034399 nuclear periphery
1.88 3.86e-03 GO:0005874 microtubule
1.50 4.51e-03 GO:0044451 nucleoplasm part
1.03 4.81e-03 GO:0044464 cell part
1.03 5.01e-03 GO:0005623 cell
4.60 5.49e-03 GO:0000795 synaptonemal complex
6.11 9.49e-03 GO:0000780 condensed nuclear chromosome, centromeric region
1.49 1.66e-02 GO:0044429 mitochondrial part
2.70 3.60e-02 GO:0016363 nuclear matrix
1.53 4.00e-02 GO:0030529 ribonucleoprotein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.51 6.70e-20 GO:0003676 nucleic acid binding
1.61 1.24e-17 GO:0003677 DNA binding
1.08 9.92e-07 GO:0005488 binding
1.54 2.84e-05 GO:0030528 transcription regulator activity
2.21 2.56e-04 GO:0043566 structure-specific DNA binding
2.43 2.92e-04 GO:0003690 double-stranded DNA binding
1.47 1.19e-03 GO:0001071 nucleic acid binding transcription factor activity
1.47 1.19e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.11 5.76e-03 GO:0005515 protein binding
7.48 8.94e-03 GO:0016885 ligase activity, forming carbon-carbon bonds
7.48 8.94e-03 GO:0032404 mismatch repair complex binding
1.46 1.37e-02 GO:0019899 enzyme binding
4.99 2.90e-02 GO:0030983 mismatched DNA binding
1.30 3.28e-02 GO:0005524 ATP binding
1.30 3.39e-02 GO:0030554 adenyl nucleotide binding
1.47 4.80e-02 GO:0043565 sequence-specific DNA binding